Coronavirus vaccine: a need for quick but humane and human-relevant action
No robust scientific evidence that animal tests reliably predict human safety and efficacy
- Bailey J, Balls M. Recent efforts to elucidate the scientific validity of animal-based drug tests by the pharmaceutical industry, pro-testing lobby groups, and animal welfare organisations. BMC Med Ethics 2019;20:16.
- Bailey J, Thew M, Balls M. Predicting human drug toxicity and safety via animal tests: can any one species predict drug toxicity in any other, and do monkeys help? Altern Lab Anim 2015;43:393-403.
- Hay M, Thomas DW, Craighead JL et al. Clinical development success rates for investigational drugs. Nat Biotechnol 2014;32:40-51.
- Thomas DW, Burns J, Audette J et al. Clinical development success rates 2006-2015. Available: http://www.amplion.com/clinical-development-success-rates. 2016pp28.
- Bailey J. An assessment of the role of chimpanzees in AIDS vaccine research. Alternatives to Laboratory Animals 2008;36:381-428.
- Bailey J. Monkey-based research on human disease: the implications of genetic differences. Altern Lab Anim 2014;42:287-317.
- BBC News. Coronavirus: Australian scientists map how immune system fights virus. Available at: https://www.bbc.co.uk/news/world-australia-51921403. 2020. Accessed 18 Mar 2020
- Thevarajan I, Nguyen THO, Koutsakos M et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. https://doi.org/10.1038/s41591-020-0819-2. Nat Med 2020
- Casadevall A, Pirofski LA. The convalescent sera option for containing COVID-19. J Clin Invest 2020